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Dermatitis Due To Enzymes
A recent review presents dermatological symptoms induced by exposure to enzymes (Kanerva & Vanhanen 2000). In the detergent industry, irritant dermatitis was common in the late 1960s, but allergic findings were rare (McMurrain 1970, Göthe et al 1972, Zachariae et al 1973). Case reports have been published of urticaria and protein contact dermatitis due to exposure to a -amylase in bakeries (Schirmer et al 1987, Morren et al 1993) and due to exposure to a -amylase, cellulase and xylanase in the enzyme manufacturing industry (Tarvainen et al 1991, Kanerva et al 1997, Kanerva et al 1998, Kanerva & Vanhanen 1999). In most of these cases, the sensitization was proved with SPTs. Few of the cases showed positivity for both the SPT and the patch test (Schirmer et al 1987, Morren et al 1993, Tarvainen et al 1991).
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